Beta thalassemia is a recessive genetic disorder of hemoglobin structure. An inherited blood disorder (usually clinically asymptomatic) resulting from the heterozygous inheritance of beta-thalassemia mutation or deletion in the beta-globin (HBB) gene on chromosome 11. Only one of the two β globin alleles contains a mutation, so β chain production is not terribly compromised and patients may be relatively asymptomatic. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body. Learn about the signs, how it’s diagnosed & treated. Thalassemia is a genetic blood disorder that impacts the ability of the blood to get oxygen to the body’s organs. Beta thalassemia minor (beta thalassemia trait) is the mildest form. This rule will usually not apply in cases of beta thalassemia, particularly beta thalassemia minor where the RBCs are not normochromic and are microcytic, and where there is a disproportionate number of … Beta thalassemia minor is usually without clinical significance. People with thalassemia minor or trait usually do not need blood transfusions because they either do not have anemia or have only a mild anemia. BETA THALASSEMIA: In beta thalassemia, the heterozygous state (called thalassemia minor) is accompanied by no symptoms or at most by very mild anemia. Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. Unlike Thalassemia Major, Thalassemia Minor has only one defective beta globin gene This condition is called beta thalassemia trait (also called beta thalassemia minor) and can cause mild anemia. If the synthesis from both genes … 1,3in beta-thalassemia minor 1,3. usually clinically asymptomatic, but may have mild anemia Folic … This is sometimes referred to as "the rule of threes." Beta thalassemia is a blood disorder that reduces the production of hemoglobin. 1,5% global population are heterozygotes for this disease. Beta thalassemia major, the homozygous state when the gene is inherited from both parents, is characterized by hemolytic anemia (i.e., early breakdown of red blood cells). Beta Thalassemia Minor (or Thalassemia Minor), a rare genetic blood disorder, is a defect in the synthesis of beta chains of hemoglobin (a protein that carries oxygen to the tissues). The one gene defect, beta thalassemia trait (minor), is asymptomatic and results in microcytosis and mild anemia. If you have mild anemia, folic acid supplements can help. You or your child may not need treatment. If one parent has beta thalassemia trait and the other parent has normal hemoglobin A, there is a 50 percent (1 in 2) chance with each pregnancy of having a child with beta thalassemia trait . β thalassemia minor is caused by a β/β o or β/β + genotype. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. Many times people with thalassemia are prescribed a supplemental B vitamin, known as folic acid, to help treat anemia. Beta thalassemia most often occurs in people of Mediterranean origin. Different forms of beta thalassemia occur if one or more of these genes are altered: If one gene is altered—a person is a “silent” carrier of beta thalassemia. Beta thalassemia trait is also known as beta thalassemia minor. The homozygous form of beta thalassemia (thalassemia major) is not immediately lethal because there is some production of Hb F, which does not contain beta chains. 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