Only these two will be seen on cosmetics in the EU, and almost certainly in North America and Australia too. Acticide MBS / MBR  Methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) are preservatives which are used in a wide variety of cosmetics and some industrial products to prevent contamination by germs, particularly bacteria. Viscosity (23°): 5.0 ±0.2 cP. Tetrasodium EDTA Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT), which are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. Following are some examples of ingredients whose names sometimes raise red flags for those consumers concerned about the presence of silicones in their products: 5-Bromo-5-Nitro-1,3-Dioxane 5-bromo-5-nitro-1,3-dioxane (trade name Bronidox) is a six-membered cyclic ether, a member of a group of molecules known as –oxanes. Because methylisothiazolinone is a strong cytotoxin, its use is under fire because of its dangers to humans and the environment. This report only considered the issue of contact sensitization. Sodium salicylate It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).It has a [14], Methylisothiazolinone is used commonly in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. A few weeks ago my eye was caught by the name of a study in the journal Contact Dermatitis, entitled “Preventing relapses of airborne allergic contact dermatitis to isothiazolinones in wall paint by painting over with an isothiazolinone‐free paint”. According to several Member States and a good number of published papers, the Amerstat 250 It has Methylisothiazolinone is an antimicrobial used to control slime-forming bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, and other industrial settings. Although the name sounds similar, it is structurally different and is highly unlikely to cause an allergic reaction in people with an MIT or Kathon allergy. Readily misc in water, lower alcohols, glycols, other hydrophilic organic solvents. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. It does not reveal its actual effects and skin compatibility. Chloromethylisothiazolinone (CMIT) (alternative for methylchloroisothiazolinone) Fennosan IT 21 This list is by no means exhaustive. [5] Isothiazolinones also are extremely toxic to fish. 2013). ved å vaske hudområdet slik at produkt ikke regelmessig blir på huden over lenger tid, eller ved å bruke hansker. [7], MIT is allergenic and cytotoxic, and this has led to some concern over its use. Again, these may be seen on an MSDS, and pose a danger because when contacting manufacturers for their MI status, unwitting customer service agents may not be aware that these represent isothiazolinone preservatives. Methylisothiazolinone (MI) is a preservative. Allergy to MI can be missed by only testing to isothiazolinone mix. It is also commonly added to householdcleaners as a substitute for formaldehyde. [4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species. 55965-84-9 – MI / MCI Blend. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food. "[11] In 2014, the European Commission Scientific Committee on Consumer Safety further issued a voluntary ban on "the mixture of Methylchloroisothiazolinone (and) Methylisothiazolinone (MCI/MI) from leave-on products such as body creams. Optiphen If you need to scrutinise lists of ingredients, check for the “isothiazol” string of letters, which is the typical ‘giveaway’, among all the numbers, brackets and hyphens. This was a very good point sent from P&G. Other names for Methylisothiazolinone (CAS No. Again, you need to identify the giveaway “isothiazol” string of letters. The most common expressions. Additional resources and links for Methylisothiazolinone. Methylisothiazolinone (technical name/synonym: 2-methyl-4-isothiazolin-3-one; CAS no. Comprehensive Toxicology Information HSDB in A. C. De Groot, A. Herxheimer: "Isothiazolinone Preservative: Cause Of A Continuing Epidemic Of Cosmetic Dermatitis", European Commission Scientific Committee on Consumer Safety Opinion on Methylisothiazolinone (P94) Submission II (Sensitization only) SCCS/1521/13, Patch testing with preservatives, antimicrobials and industrial biocides. Euxyl K 100 Methylisothiazolinone and other isothiazolinone-derived biocides are utilized for controlling microbial growth in water-containing solutions. “Several Member States raised concern on the use of Methylisothiazolinone (MIT), as data demonstrates that MIT is a sensitizer in animals and a contact allergen in humans. * Avoid products that list any of the following names … [8][9] A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT. "[11], "It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized. Methylchloroisothiazolinone: Uses and Side Effect Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5-15% of CMIT/MIT. You may also encounter some suspect ingredients may look superficially or partly like methylisothiazolinone – but are in fact fine. I kosmetikk merkes MI og MCI i ingredienslisten som henholdsvis «methylisothiazolinone» og methylchloroisothiazolinone. [1] What Does Benzisothiazolinone Do in Our products? Salicat MM / MI-10 / K100 / K145 Other names for MI Methylisothiazolinone and other isothiazolinone preservatives can appear in a number of guises. Kathon CG / LX / WT Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]. d 20 1.19. And many similar variations. The following information was extracted from the NICNAS Inventory Multi-tiered Assessment Prioritisation (IMAP) human health Tier II assessment report for 3-isothiazolone, 2-methyl-, publicly available on the NICNAS website. Curious, I emailed one of the three authors, and asked … (That said, some paint manufacturers refer to the preservatives as “thiazoles” or “thiazoline compounds”.). This substance is a component inKathon and Grotan preservatives. Methylpropional On March 27, 2014, the European Commission’s Scientific Committee on Consumer Safety issued an opinion on the safety of Methylisothiazolinone. They may also appear on other products, such as household cleaning goods and other products. Special Mx 323. Methyleugenol This ingredient has recently been blamed for a rise in the skin disease Eczema and many other allergic reactions. Other Concerns; Functions; About the Chemical; Synonyms; Use restrictions (high), Neurotoxicity (low), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (moderate) preservative. Proxel AQ / PL / XL2 Publication EPA-738-F-98-008, A. Schnuch, J. Geier, W. Utur, P. J. Frosch: ". Alternative names of isothiazolinone mix Kathon®, Kathon CG®, Kathon 886® Methylchloroisothiazolinone (MCI) Methylisothiazolinone (MI), a related allergen, was declared the Contact Allergen of the Year for 2013 by the Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. Methylisothiazolinone (MIT) prices in other regions 7. Product number-Other names: methylisothiazolin-3-one: 1.3 Recommended use of the chemical and restrictions on use. Methylisothiazolinone or MIT is a preservative used in many consumer goods including cosmetic products, to preserve product quality and ensure consumer safety by preventing the growth of microbes. Methylisothiazolinone and other isothiazolinone preservatives can appear in a number of guises. Mitco CC 31/32 L And many similar variations. Frisører og andre grupper som arbeider med denne type stoffer i profesjonell sammenheng, bør prøve å begrense hudeksponeringen f.eks. The full list of permitted compounds in fragrance, Isothiazolinone test kits, dish soaps and cosmetics, Coronavirus and allergic contact dermatitis, MI free hairspray, hair mousse and hair gel, Suma’s Ecoleaf Hand Soap: reporting non-compliant use of benzisothiazolinone. [2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT), which are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. In that case it will be called Kathon CG or Euxyl K100. Results from a multicentre study, European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP), adopted 2004, "European Commission - PRESS RELEASES - Press release - Consumers: Commission improves safety of cosmetics", "Health Canada - "December 2015 Changes to the Cosmetic Ingredient Hotlist, Growing Scrutiny for an Allergy Trigger Used in Personal Care Products, 2014 EPA Re-registration Review Docket with Public Commentary, Reregistration Eligibility Decision of MIT by US EPA, Material Safety Data Sheet for product containing 0.1-1% MIT, Commission Scientific Committee on Consumer Safety Opinion on Methylisothiazolinone (P94) Submission II (Sensitization only) SCCS/1521/13, Methylisothiazolinone at the National Library of Medicine, Photo album of self reported reactions to methylisothiazolinone, https://en.wikipedia.org/w/index.php?title=Methylisothiazolinone&oldid=984932762, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from October 2020, Creative Commons Attribution-ShareAlike License, This page was last edited on 22 October 2020, at 23:35. [23] The New York Times reported that some companies are even considering removing the biocide from products that are routinely rinsed off shortly after application. Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) may be hard to pronounce, but they can be even harder on the body. Salimix MCI Preservatives and Antioxidants : Uses advised against: no data available: 1.4 Supplier's details. These are rarely seen on products, but may appear in, for example, material safety data sheets (MSDSs), such as those produced for paints. 26172-55-4 – Methylchloroisothiazolinone (MCI) In North America (and perhaps elsewhere outside the EU), MI and/or MCI can theoretically ‘hide’ in the term ‘fragrance’ or ‘parfum’, given it is one of the permitted chemicals in any blend that can be described as such. [6] These compounds are present in a very large number of commonly used cosmetics. Sensitization to this family of preservatives was observed as early as the late 1980s. However, the following non-isothiazolinone preservatives should be safe for you: Benzyl alcohol Benzisothiazolinone, also called BIT, is an off-white to yellowish liquid antimicrobial substance. Very small companies sometimes get these things a bit wrong and put the trade name on. Imadozolidinyl urea … Methylisothiazolinone (MI) was listed in Annex V/57 of Regulation (EC) No 1223/2009 to be used as preservative at maximum concentration of 0.01% (100 ppm) in cosmetics products. Here’s one example. Remember that fragrances can trigger allergies in their own right. This substance is a preservative used in personal hygiene products (suchas shampoos, lotions, emulsions, and sun screens), and in industrial coolingoils, cutting oils, and paper finishes. Common names and synonyms CAS number EC number methylisothiazolinone methylisothiazolinone 2682-20-4 none European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. These ‘false enemies’ include: Methyl benzoate Methylisothiazolinone is a widely-used preservative; has been associated with allergic reactions. Phenoxyethanol Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions. It can be found under the name "methylisothiazolinone". Insol in petrolatum. Product name: methylisothiazolinone: 1.2 Other means of identification. Piror P109 Sharomix MI / MT / MCI [citation needed] Colgate-Palmolive had added it as an ingredient in a mouthwash put onto the market in August 2014 with the name Colgate Total Lasting White. The measure is aimed at reducing the risk from and the incidence of skin allergies. Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible."[21]. One of the more common products of this kind used to be Kathon®, a 1.5%-aqueous solution consisting of 1 part methylisothiazolinone (CAS No 2682-20-4), and 3 parts of chloromethylisothiazolinone (CAS No 26172-55-4). It may take 2 to 3 weeks of avoiding exposure before improvement of your eruption begins. The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. These are rarely seen on products, but may appear in, for example, material safety data sheets (MSDSs), such as those produced for paints. The measure will apply for products placed on the market after 16 July 2015. Parmetol A / DF / K Alternative names of isothiazolinone mix. Company: WWW.GuideChem.COM: Address: 8F, Block C, No.3 Building, Zijin Plaza, … Benzisothiazolinone (BIT) Methylpropanediol Methylisothiazolinone (MIT) is a preservative that is found in a wide array of liquid cosmetics, personal care products and cleaning products on the market today. Grotan K / TK2 Methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) and the serious skin allergies they cause, plus MI / MCI free household detergents, cosmetics, make-up and other products. INCI methylisothiazolinone 3.1.2. Methylisothiazolinone and methylchloroisothiazolinone allergy — news, information and support. It is also used to control the growth of mold, mildew, and sapstain on wood products. Methylisothiazolinone, MIT or MI is the latest approved preservative in Europe and it’s very very commonly used in producing skin care products. ) or 2-methyl-4-isothiazolin-3-one ; 2-methyl-3 ( 2H ) -one other 2-methyl-4-isothiazolin-3-one 3.1.3 preservatives that are usually sold used! 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